反应详情

Trifluoromethanesulfonic anhydride (0.109 mL, 0.65 mmol) was added to a solution of (trimethylsilyl)ethyl (±)-(E)-4-(4-(2,2-dimethyl-6-oxocyclohexyl)but-3-en-1-ynyl)benzoate (Compound G, 150 mg, 0.38 mmol) and 2,6-di-tert-butyl-4-methylpyridine (DBMP, 218 mg, 1.06 mmol) in dichloromethane (4 mL). The flask was sealed with a plastic cap and stirred for 2 days at room temperature. The solution was diluted with ethyl acetate and washed with 10% aqueous H3PO4. The layers were separated and the aqueous layer extracted three times with ethyl acetate. The combined organic layers were washed with 5% aqueous NaHCO3, and brine, and dried (Na2SO4). The solvents were removed under reduced pressure, and the residue was purified by silica gel chromatography (10:1, hexane:ethyl acetate) to give the title compounds as a 1:1 mixture of isomers. The compounds were separated by HPLC using a Whatman Partisil-10 1×50 cm column (95:5, hexane:ethyl acetate) to provide the title compound as a colorless oil:

1. customThe flask was sealed with
2. customa plastic cap
3. washwashed with 10% aqueous H3PO4
4. customThe layers were separated
5. extractionthe aqueous layer extracted three times with ethyl acetate
6. washThe combined organic layers were washed with 5% aqueous NaHCO3, and brine
7. dry with materialdried (Na2SO4)
8. customThe solvents were removed under reduced pressure
9. customthe residue was purified by silica gel chromatography (10:1, hexane:ethyl acetate)