Isobutyryl chloride → HCID 9951816, compound

Participants

Reaction Steps

The title compound, a colorless oil, was prepared from ethyl (+)-(E)-4-(4-(6-hydroxy-2-methylcyclohex-1-enyl)but-3-en-1-ynyl)benzoate (Compound 1b, 25 mg, 0.081 mmol) and iso-butyryl chloride (0.084 mL, 0.81 mmol) as described in General Procedure C. [α]D=+138 (EtOAc), PNMR (300 MHz, CDCl3) δ 1.17 (d, 6 H, J=7.7 Hz), 1.39 (t, 3 H, J=7.1 Hz), 1.67 (m, 3 H), 1.92 (s, 3 H), 1.96 (m, 1 H), 2.21 (m, 2 H), 2.54 (m, 1 H, J=7.7 Hz), 4.3 7 (q, 2 H, J=7.1 Hz), 5.66 (s, 1 H), 5.67 (d, 1 H, J=16 Hz), 7.0 8 (d, 1 H, J=16 Hz), 7.48 (d, 2 H, J=8.3 Hz), 7.98 (d, 2 H, J=8.3 Hz).

Provenance & Evidence