反应详情

12 mmol of N-bromosuccinimide are added to 10 mmol of 5,6-dimethoxyphthalide dissolved in dichloromethane and then the reaction mixture, illuminated with a halogen lamp, is heated at reflux for 5 hours. The mixture is then brought to ambient temperature and filtered, and the filtrate is subsequently evaporated, toluene is added, the suspension obtained is filtered and the filtrate is evaporated. The residue obtained is filtered through silica to yield the expected product.

1. customthe reaction mixture, illuminated with a halogen lamp
2. temperatureis heated
3. temperatureat reflux for 5 hours
4. customis then brought to ambient temperature
5. filtrationfiltered
6. customthe filtrate is subsequently evaporated
7. additiontoluene is added
8. customthe suspension obtained
9. filtrationis filtered
10. customthe filtrate is evaporated
11. customThe residue obtained
12. filtrationis filtered through silica