HCID 69843677, compound → HCID 69842979, compound

HRID 991939Notes

Reaction equation

HRID 991939 reaction equation
[N:1]1([C:6]([NH2:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:9][C:10]1([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[2H]C(Cl)(Cl)Cl.CO[2H]>>[N:1]1([C:6]([NH2:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:9][C:10]1([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][N:13]([CH2:14][CH2:15][C:10]2[CH:11]=[CH:12][C:4]([C:5]3[CH:4]=[CH:3][CH:2]=[C:6]([NH2:8])[N:1]=3)=[CH:3][CH:2]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 69843677HCID 69843677, compoundHCID 131722572HCID 131722572, compound

Product 1

HCID 69842979HCID 69842979, compoundYield 39%

Procedure

Prepared as in Example 1, using 4-amino-piperidine-4-carboxylic acid pyrrolidine-amide, in 39% yield, mp 220° C. (dec.) as the hydrochloride salt.

Workup

  1. customPrepared as in Example 1

Sources & evidence

ORD record
ord-332f2241690a4e7d8ffdff5803b16349
Source dataset
uspto-grants-2002_10
Patent number
US06465491B2

Reaction notes

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