huagongshe.com
HRID991954

反应详情

EQUATION

反应方程式

HRID 991954 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)CC=O
HCID76335

3,3-Dimethylbutyraldehyde

C6H12O

结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
HCID134601

Aspartame

C14H18N2O5

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NCCC(C)(C)C
HCID9810996

Neotame

C20H30N2O5

PROCEDURE

实验过程

U.S. Pat. No. 5,728,862 describes a method comprising treating a solution of aspartame and 3,3-dimethylbutyraldehyde, in an organic solvent with hydrogen in the presence of a catalyst as a reducing agent. After removal of the catalyst, water was added to form an aqueous/organic solvent solution containing about 17% to about 30% of the organic solvent, by weight, from which the neotame was obtained by precipitation and filtration.

WORKUP

后处理

  1. customAfter removal of the catalyst, water
  2. additionwas added
  3. customto form an aqueous/organic solvent solution