Phosphorus tribromide → HCID 18415110, compound

Participants

Reaction Steps

A solution of PBr3 (401 mg, 1.48 mmol) in 10 ml of CH2Cl2 was added dropwise, under nitrogen, to a stirred solution of the above alcohol (Example 16, 850 mg) in 20 ml CH2C12 at 0° C. The reaction mixture was left to stand at room temperature over night and then diluted with CH2Cl2. The organic phase was washed with water, dried over MgSO4 and concentrated. The residue was purified by column chromathography (silica gel, 9:1 petroleum-ether/EtOAc) to give 465 mg of 3,5-dimethyl-4-(4-hydroxy-3-isopropyl-phenoxy)benzylbromide

Provenance & Evidence