反应详情

0.45 g (1 mmol) of 2-(2-hydroxy-ethyl-amino)-6-(4-benzyloxycarbonylamino-phenyl-amino)-9-ethyl-9H-purine (prepared according to Example 107) are hydrogenated with 0.1 g of 10% Pd/C in 8 ml of methanol at RT for 5 h. The catalyst is filtered off, the residue on the filter is rinsed with dioxane/water (95:5) and the solvent is removed in vacuo. The desired compound, 6-(4-amino-phenyl-amino)-9-ethyl-2-(2-hydroxy-ethyl-amino)-9H-purine, can be isolated in crystalline form by this procedure; m.p. 210° C.; FAB-MS: (M+H)+=314; Rf=0.15 (methylene chloride:methanol=9:1).

1. filtrationThe catalyst is filtered off
2. washthe residue on the filter is rinsed with dioxane/water (95:5)
3. customthe solvent is removed in vacuo