5-Bromoindole → 5-Bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

HRID 992006Notes

Reaction equation

HRID 992006 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[Br:20]C1C=C2C(=CC=1)NC=C2>>[O:4]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([Br:20])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:1][CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 249055-BromoindoleHCID 27638573-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

Product 1

HCID 27639895-Bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indoleYield 78%

Procedure

This compound was prepared in the manner described above for intermediate 1a by replacing indole with 5-bromoindole (7.84 g, 40 mmol)) to afford 10.5 g (78%) of the title compound as a white solid; MS EI m/e 333 (M30).

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-3c180ae8730946b2b44d42dc7d21699a
Source dataset
uspto-grants-2002_10
Patent number
US06465482B2

Reaction notes

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