HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-4-fluoro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole | HCID 10848753 | — |
| Reactant | 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-4-fluoro-1H-indole | HCID 18414055 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-4-fluoro-1H-indole | HCID 18414088 | 70% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 2a by replacing 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-4-fluoro-1H-indole (6.3 g)) to afford 4.44 g (70%) of the title compound as a white solid: mp 161-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465482B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-22e503a07b294772b51d01863f2ced78 |
| Source note | uspto-grants-2002_10 |