3-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indole → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indole

HRID 992015Notes

Reaction equation

HRID 992015 reaction equation
O1C2(CCC(C3C4C(=CC=CC=4)NC=3)CC2)OCC1.[O:20]1[C:24]2([CH2:29][CH2:28][C:27]([C:30]3[C:38]4[C:33](=[CH:34][CH:35]=[C:36]([C:39]#[N:40])[CH:37]=4)[NH:32][CH:31]=3)=[CH:26][CH2:25]2)[O:23][CH2:22][CH2:21]1>>[O:23]1[C:24]2([CH2:29][CH2:28][CH:27]([C:30]3[C:38]4[C:33](=[CH:34][CH:35]=[C:36]([C:39]#[N:40])[CH:37]=4)[NH:32][CH:31]=3)[CH2:26][CH2:25]2)[O:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 108487533-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-indoleHCID 155219723-(1,4-Dioxaspiro[4.5]dec-7-EN-8-YL)-1H-indole-5-carbonitrile

Product 1

HCID 155219733-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indoleYield 95%

Procedure

This compound was prepared in the manner described above for intermediate 2a by replacing 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-7-en-8-yl)-5-cyano-1H-indole (54.6 g)) to afford 52.12 g (95%) of the title compound as a white solid in 95% (52.12 g) yield as a white solid: mp 153-155° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-6b218deef1834168b3a5cf2c1bc494c9
Source dataset
uspto-grants-2002_10
Patent number
US06465482B2

Reaction notes

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