HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromopropane → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-n-propyl-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromopropane | HCID 7840 | — |
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-ethyl-indole | HCID 18414062 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-n-propyl-indole | HCID 18414064 | 75% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 5b by replacing ethylbromide with n-propylbromide (13.1 g, 11 mmol) to afford 4.33 g (75%) of the title compound as a oil: MS EI m/e 324 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465482B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-7cea1c677f64428abe0658c6b357229b |
| Source note | uspto-grants-2002_10 |