HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-benzyl-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-ethyl-indole | HCID 18414062 | — |
| Product | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-benzyl-indole | HCID 18414121 | 57% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 5b by replacing ethylbromide with benzylbromide (14.3 g, 84 mmol) to afford 6.04 g (57%) of the title compound as a white solid: mp 129-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465482B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-e0f16882abfc4142b6c5733b35349c7e |
| Source note | uspto-grants-2002_10 |