HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Cyano-1-methyl-3-indolyl)cyclohexanone → 4-(5-Cyano-1-benzyl-3-indolyl)-cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Cyano-1-methyl-3-indolyl)cyclohexanone | HCID 15481282 | — |
| Reactant | 3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-benzyl-indole | HCID 18414121 | — |
| Product | 4-(5-Cyano-1-benzyl-3-indolyl)-cyclohexanone | HCID 18414169 | 63% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 6a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-methyl-indole with 3-(1,4-dioxa-spiro[4,5]-dec-8-yl)-5-cyano-1-benzyl-indole (6.43 g, 20 mmol) to afford 3.49 g (63%) of the title compound as a white solid: mp 115-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465482B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-632ad143d3ae44b1bd8cccaa74d92414 |
| Source note | uspto-grants-2002_10 |