HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Cyano-1-methyl-3-indolyl)cyclohexanone → 4-(5-Cyano-1-isopropyl-3-indolyl)-cyclohexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Cyano-1-methyl-3-indolyl)cyclohexanone | HCID 15481282 | — |
| Reactant | 3-(1,4-Dioxa-spiro[4,5]-dec-8-yl)-5-cyano-1-isopropyl-indole | HCID 18414061 | — |
| Product | 4-(5-Cyano-1-isopropyl-3-indolyl)-cyclohexanone | HCID 18414148 | 77.1% |
Reaction Steps
This compound was prepared in the manner described above for intermediate 6a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-5-cyano-1-methyl-indole with 3-(1,4-dioxa-spiro[4,5]-dec-8-yl)-5-cyano-1-isopropyl-indole (5.86 g, 16 mmol) to afford 3.46 g (63%) of the title compound as a white solid: mp 106-107° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06465482B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-1ed860f26a284be690171ee6994605fa |
| Source note | uspto-grants-2002_10 |