Water → HCID 178480356, compound

Participants

Reaction Steps

The trans was obtained by the process described for Example 73 by combining 0.30 g (0.60 mmol) 8-[4-[(Trans)-4-(5-cyano-1-methyl-1H-indole-3-yl)cyclohexyl]-1-piperazinyl]-6-quinolinecarbaldehyde, 0.48 g (5.5 mmol) NaClO2, 0.48 g (4.1mmol) NaH2PO4, 24 mL t-BuOH, 3 mL CH3CHC(CH3)2, and 6 ml water. The product fractions were pooled, striped, and treated with 54 mg (0.60 mmol) of (CO2H)2 in absolute EtOH to give 97mg (0.16 mmol, a 10% yield) mp: 275° C. MS (ES) m/z: 494 (MH)+.

Provenance & Evidence