5,6-Difluoro-2-bromonaphthalene → HCID 178447939, compound

HRID 992191Notes

Reaction equation

HRID 992191 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Br)=[CH:7]2.[CH2:14]([CH:17]1[CH2:22][CH2:21][CH:20]([CH2:23][CH:24]=O)[CH2:19][CH2:18]1)[CH2:15][CH3:16].CC(C)([O-])C.[K+]>>[F:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH2:24][CH2:23][C@H:20]1[CH2:19][CH2:18][C@H:17]([CH2:14][CH2:15][CH3:16])[CH2:22][CH2:21]1)=[CH:7]2

Participants

4

Reactant 3

HCID 114138325,6-Difluoro-2-bromonaphthaleneHCID 149934692-((1s,4r)-4-Propylcyclohexyl)acetaldehydeHCID 23665647Potassium tert-butoxide

Product 1

HCID 178447939HCID 178447939, compound

Procedure

The procedure of Example14 was followed except that 5,6-difluoro-2-bromonaphthalene was used instead of 6-fluoro-2-bromonaphthalene, 4-propylcyclohexaneethanal was used instead of 4-propylcyclohexanone and isomerization with potassium t-butoxide was not effected to obtain 5,6-difluoro-2-[2-(trans-4-propylcyclohexyl)ethyl]naphthalene.

Sources & evidence

ORD record
ord-9544322e316a4fd9b554bd7940e82b65
Source dataset
uspto-grants-2002_10
Patent number
US06468607B1

Reaction notes

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