HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → 2-(Thiophen-2-yl)-1,3-thiazole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Tempo | HCID 2724126 | — |
| Reactant | [2-(2-Thienyl)-1,3-thiazol-4-YL]methanol | HCID 2776319 | — |
| Reactant | Sodium Hypochlorite | HCID 23665760 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Thiophen-2-yl)-1,3-thiazole-4-carbaldehyde | HCID 18411551 | — |
Reaction Steps
TEMPO (5.1 mg; 0.0329 mmol) and a solution of KBr (39.2 mg; 0.329 mmol) in water (0.5 ml) were added to a solution of (2-thiophen-2-ylthiazole-4-yl)methanol (0.65 g; 3.29 mmol) in CH2Cl2 (12 ml), followed, after cooling to 0-5° C., by dropwise addition of a solution of 7.1% sodium hypochlorite (4.1 ml; 4.1 mmol) and NaHCO3 (245 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06468979B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-39b93f7759374974b15ce23454ff4d93 |
| Source note | uspto-grants-2002_10 |