Methanol → 1-Tert-butyl 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate

HRID 99228Notes

Reaction equation

HRID 99228 reaction equation
[BH4-:19].[CH3:21][OH:22].[Na+:20].[O:1]=[C:2]1[CH:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[OH:1][CH:2]1[CH:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 112768931-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

Product 1

HCID 185348061-Tert-butyl 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate

Sources & evidence

ORD record
ord-aafc834161994af9af779bbc547ed84f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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