HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Methoxyphenyl)ethyl 4-methylbenzenesulfonate → (S)-N-(1-(2-(4-methoxyphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Methoxyphenyl)ethyl 4-methylbenzenesulfonate | HCID 285384 | — |
| Reactant | (S)-N-(pyrrolidin-3-yl)-1-adamantanecarboxamide | HCID 49760538 | — |
| Product | (S)-N-(1-(2-(4-methoxyphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide | HCID 9864780 | 18.8% |
Reaction Steps
(S)-N-(Pyrrolidin-3-yl)-1-adamantanecarboxamide (0.38 g) and 2-(4-methoxyphenyl)ethyl p-toluenesulfonate (0.56 g) were reacted under the same conditions as in Example 1 to give (S)-N-(1-(2-(4-methoxyphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide (0.11 g), melting point 81-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06468998B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-5e7e1d10d8ff46409c4a05040488400b |
| Source note | uspto-grants-2002_10 |