HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-N-(1-(2-(4-trifluoromethylphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 18411913 | HCID 18411913 | — |
| Reactant | Isopropanol hydrochloride | HCID 21912024 | — |
| Reactant | (S)-N-(pyrrolidin-3-yl)-1-adamantanecarboxamide | HCID 49760538 | — |
| Product | (S)-N-(1-(2-(4-trifluoromethylphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide hydrochloride | HCID 86758575 | — |
Reaction Steps
(S)-N-(Pyrrolidin-3-yl)-1-adamantanecarboxamide (0.5 g) and 2-(4-trifluoromethylphenyl)ethyl p-toluenesulfonate (0.69 g) were reacted under the same conditions as in Example 1. After the same post-treatment as in Example 1, the obtained compound was converted to hydrochloride with 30% hydrochloric acid-isopropanol to give (S)-N-(1-(2-(4-trifluoromethylphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide hydrochloride 1/2 hydrate (0.51 g), melting point 214-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06468998B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-4cc91c93e68949cfaee2259b9bf54c04 |
| Source note | uspto-grants-2002_10 |