HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70172047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 18411885 | HCID 18411885 | — |
| Reactant | Isopropanol hydrochloride | HCID 21912024 | — |
| Reactant | (S)-N-(pyrrolidin-3-yl)-1-adamantanecarboxamide | HCID 49760538 | — |
| Product | HCID 70172047 | HCID 70172047 | — |
Reaction Steps
(S)-N-(Pyrrolidin-3-yl)-1-adamantanecarboxamide (0.5 g) and 2-(3-trifluoromethylphenyl)ethyl p-toluenesulfonate (0.69 g) were reacted under the same conditions as in Example 1. After the same post-treatment as in Example 1, the obtained compound was converted to hydrochloride with 30% hydrochloric acid-isopropanol to give (S)-N-(1-(2-(3-trifluoromethylphenyl)ethyl)pyrrolidin-3-yl)-1-adamantanecarboxamide hydrochloride monohydrate (0.44 g), melting point 160-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06468998B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-cddc56df92de4925b97cea9879cea907 |
| Source note | uspto-grants-2002_10 |