(3-Bromopropyl)benzene → HCID 9820548, compound

HRID 992289Notes

Reaction equation

HRID 992289 reaction equation
[NH:1]1[CH2:5][CH2:4][C@H:3]([NH:6][C:7]([C:9]23[CH2:18][CH:13]4[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]4)[CH2:10]2)[CH2:16]3)=[O:8])[CH2:2]1.Br[CH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([CH2:22][CH2:21][CH2:20][N:1]2[CH2:5][CH2:4][C@H:3]([NH:6][C:7]([C:9]34[CH2:18][CH:13]5[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]5)[CH2:10]3)[CH2:16]4)=[O:8])[CH2:2]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 12503(3-Bromopropyl)benzeneHCID 49760538(S)-N-(pyrrolidin-3-yl)-1-adamantanecarboxamide

Product 1

HCID 9820548HCID 9820548, compoundYield 21.4%

Procedure

(S)-N-(Pyrrolidin-3-yl)-1-adamantanecarboxamide (0.38 g) and 3-bromopropylbenzene (0.37 g) were reacted under the same conditions as in Example 1 to give (S)-N-(1-(3-phenylpropyl)pyrrolidin-3-yl)-1-adamantanecarboxamide (0.12 g), melting point 118-120° C.

Sources & evidence

ORD record
ord-8feea58c16aa4d99b867bf1b4e9f0f09
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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