1-Bromo-4-phenylbutane → HCID 9800041, compound

HRID 992292Notes

Reaction equation

HRID 992292 reaction equation
[NH:1]1[CH2:5][CH2:4][C@H:3]([NH:6][C:7]([C:9]23[CH2:18][CH:13]4[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]4)[CH2:10]2)[CH2:16]3)=[O:8])[CH2:2]1.Br[CH2:20][CH2:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:24]1([CH2:23][CH2:22][CH2:21][CH2:20][N:1]2[CH2:5][CH2:4][C@H:3]([NH:6][C:7]([C:9]34[CH2:18][CH:13]5[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]5)[CH2:10]3)[CH2:16]4)=[O:8])[CH2:2]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2596681-Bromo-4-phenylbutaneHCID 49760538(S)-N-(pyrrolidin-3-yl)-1-adamantanecarboxamide

Product 1

HCID 9800041HCID 9800041, compoundYield 12.5%

Procedure

(S)-N-(Pyrrolidin-3-yl)-1-adamantanecarboxamide (0.38 g) and 4-bromobutylbenzene (0.39 g) were reacted under the same conditions as in Example 1 to give (S)-N-(1-(4-phenylbutyl)pyrrolidin-3-yl)-1-adamantanecarboxamide (0.073 g), melting point 82-84° C.

Sources & evidence

ORD record
ord-b8ed1989666a4741a63de6191eb6863c
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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