Dicyclohexylacetic acid → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)dicyclohexylacetamide

HRID 992296Notes

Reaction equation

HRID 992296 reaction equation
[CH:1]1([CH:7]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:19]1>>[C:25]1([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][C@H:18]([NH:17][C:8](=[O:10])[CH:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:19]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 3661562Dicyclohexylacetic acidHCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine

Product 1

HCID 59915885(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)dicyclohexylacetamide

Procedure

Dicyclohexylacetic acid and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)dicyclohexylacetamide.

Sources & evidence

ORD record
ord-b7e74e65399e4530a03fe0f77d0d5e12
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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