2-Cyclopentylphenylacetic acid → N-((S)-1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-cyclopentylphenylacetamide

HRID 992299Notes

Reaction equation

HRID 992299 reaction equation
[CH:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[CH2:12][C:13]([OH:15])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:16][C@H:17]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:18]1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][CH2:22][N:19]2[CH2:20][CH2:21][C@H:17]([NH:16][C:13](=[O:15])[CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH2:18]2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 184119152-Cyclopentylphenylacetic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 70176493N-((S)-1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-cyclopentylphenylacetamide

Procedure

2-Cyclopentylphenylacetic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give N-((S)-1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-cyclopentylphenylacetamide.

Sources & evidence

ORD record
ord-846f2c9bc918469fbdf1e0294e16099d
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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