9,10-Dihydroanthracene-9-carboxylic acid → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9,10-dihydroanthracene-9-carboxamide

HRID 992300Notes

Reaction equation

HRID 992300 reaction equation
[CH:1]1[C:14]2[CH:13]([C:15](O)=[O:16])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[NH2:18][C@H:19]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:20]1>>[C:26]1([CH2:25][CH2:24][N:21]2[CH2:22][CH2:23][C@H:19]([NH:18][C:15]([CH:13]3[C:12]4[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=4[CH2:6][C:5]4[C:14]3=[CH:1][CH:2]=[CH:3][CH:4]=4)=[O:16])[CH2:20]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 2926559,10-Dihydroanthracene-9-carboxylic acidHCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine

Product 1

HCID 59915883(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9,10-dihydroanthracene-9-carboxamide

Procedure

9,10-Dihydroanthracene-9-carboxylic acid and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-9,10-dihydroanthracene-9-carboxamide.

Sources & evidence

ORD record
ord-b932736327064211b37214c1c0269a25
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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