Xanthene-9-carboxylic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-9-xanthenylcarboxamide

HRID 992305Notes

Reaction equation

HRID 992305 reaction equation
[CH:1]1[C:14]2[CH:13]([C:15]([OH:17])=O)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[NH2:18][C@H:19]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH2:20]1>>[F:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][CH2:24][N:21]2[CH2:22][CH2:23][C@H:19]([NH:18][C:15]([CH:13]3[C:14]4[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=4[O:6][C:7]4[C:12]3=[CH:11][CH:10]=[CH:9][CH:8]=4)=[O:17])[CH2:20]2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 65736Xanthene-9-carboxylic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 22888060(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-9-xanthenylcarboxamide

Procedure

9-Xanthenylcarboxylic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-9-xanthenylcarboxamide.

Sources & evidence

ORD record
ord-ec981f548021465bac52d13411cbf290
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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