(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide

HRID 992308Notes

Reaction equation

HRID 992308 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:8]([OH:10])=O.[NH2:17][C@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:19]1>>[C:25]1([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][C@H:18]([NH:17][C:8](=[O:10])[CH:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[CH2:19]2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamineHCID 18411894Bis(2-pyridyl)acetic acid

Product 1

HCID 59915942(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide

Procedure

Bis(2-pyridyl)acetic acid and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide.

Sources & evidence

ORD record
ord-d8be3b82c64e4e9c92ec0ef3da36cb4e
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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