Bis(2-pyridyl)acetic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide

HRID 992309Notes

Reaction equation

HRID 992309 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:8]([OH:10])=O.[NH2:17][C@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:19]1>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][C@H:18]([NH:17][C:8](=[O:10])[CH:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[CH2:19]2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 18411894Bis(2-pyridyl)acetic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 59915893(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide

Procedure

Bis(2-pyridyl)acetic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)bis(2-pyridyl)acetamide.

Sources & evidence

ORD record
ord-b26e6d41bcf046bf8b0ecaece2ee8e93
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

Loading…