2-(2-Pyridyl)phenylacetic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-(2-pyridyl)phenylacetamide

HRID 992311Notes

Reaction equation

HRID 992311 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][C:14]([OH:16])=O.[NH2:17][C@H:18]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH2:19]1>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][C@H:18]([NH:17][C:14](=[O:16])[CH2:13][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=3[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[CH2:19]2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 219574362-(2-Pyridyl)phenylacetic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 70172055(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-(2-pyridyl)phenylacetamide

Procedure

2-(2-Pyridyl)phenylacetic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-2-(2-pyridyl)phenylacetamide.

Sources & evidence

ORD record
ord-533b2914873642e9baa7a1041678ac5c
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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