7-Norbornadienecarboxylic acid → (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornadienecarboxamide

HRID 992315Notes

Reaction equation

HRID 992315 reaction equation
[C:1]12[CH:7]([C:8]([OH:10])=O)[C:4]([CH2:5][CH2:6]1)=[CH:3][CH:2]=2.[NH2:11][C@H:12]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:13]1>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][N:14]2[CH2:15][CH2:16][C@H:12]([NH:11][C:8]([CH:7]3[C:4]4[CH2:5][CH2:6][C:1]3=[CH:2][CH:3]=4)=[O:10])[CH2:13]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 553034877-Norbornadienecarboxylic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 70172039(S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornadienecarboxamide

Procedure

7-Norbornadienecarboxylic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-7-norbornadienecarboxamide.

Sources & evidence

ORD record
ord-8bc8db81195948faa6cf27222bc92304
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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