1-Cyclohexyl-1-cyclopentanecarboxylic acid → HCID 59915884, compound

HRID 992319Notes

Reaction equation

HRID 992319 reaction equation
[CH:1]1([C:7]2([C:12]([OH:14])=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH2:17]1>>[F:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH2:21][N:18]2[CH2:19][CH2:20][C@H:16]([NH:15][C:12]([C:7]3([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)[CH2:8][CH2:9][CH2:10][CH2:11]3)=[O:14])[CH2:17]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 184119421-Cyclohexyl-1-cyclopentanecarboxylic acidHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 59915884HCID 59915884, compound

Procedure

1-Cyclohexyl-1-cyclopentanecarboxylic acid and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 23 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-cyclohexyl-1-cyclopentanecarboxamide.

Sources & evidence

ORD record
ord-f8a0d927b3c242559982914c36dcc43a
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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