HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Bis(2-fluorophenyl)acetyl chloride → (S)-2,2-bis(2-fluorophenyl)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Bis(2-fluorophenyl)acetyl chloride | HCID 18411879 | — |
| Reactant | (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine | HCID 59915932 | — |
| Product | (S)-2,2-bis(2-fluorophenyl)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)acetamide | HCID 59915866 | 32.8% |
Reaction Steps
2,2-Bis(2-fluorophenyl)acetyl chloride (0.74 g) and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine (0.42 g) were reacted under the same conditions as in Example 53 to give (S)-2,2-bis(2-fluorophenyl)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)acetamide (0.29 g), melting point 107-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06468998B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-f030cfad1f154c51bbf49cde958b5b93 |
| Source note | uspto-grants-2002_10 |