Tricyclo[3.3.1.1~3,7~]decane-1-sulfonyl chloride → HCID 59915910, compound

HRID 992326Notes

Reaction equation

HRID 992326 reaction equation
[C:1]12([S:11](Cl)(=[O:13])=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH2:17]1>>[F:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH2:21][N:18]2[CH2:19][CH2:20][C@H:16]([NH:15][S:11]([C:1]34[CH2:10][CH:5]5[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]5)[CH2:2]3)[CH2:8]4)(=[O:13])=[O:12])[CH2:17]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 12794401Tricyclo[3.3.1.1~3,7~]decane-1-sulfonyl chlorideHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 59915910HCID 59915910, compound

Procedure

1-Adamantanesulfonyl chloride and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-adamantanesulfonamide.

Sources & evidence

ORD record
ord-8dc23c860100432ab0401e3332059eeb
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

Loading…