HCID 18411808, compound → HCID 70173912, compound

HRID 992331Notes

Reaction equation

HRID 992331 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH:4]3[C:11](Cl)=[O:12])[CH2:2]1)[CH2:8]2.[NH2:14][C@H:15]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:16]1>>[F:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:15]([NH:14][C:11]([CH:4]3[CH:5]4[CH2:10][N:1]5[CH2:8][CH:7]([CH2:9][C@@H:3]3[CH2:2]5)[CH2:6]4)=[O:12])[CH2:16]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 18411808HCID 18411808, compoundHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 70173912HCID 70173912, compound

Procedure

1-Azaadamantane-4-carbonyl chloride and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-azaadamantane-4-carboxamide.

Sources & evidence

ORD record
ord-907685310ed24aadbb916e0ad045f1e4
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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