3-Aminotricyclo[3.3.1.13,7]decane-1-carbonyl chloride → HCID 70176410, compound

HRID 992332Notes

Reaction equation

HRID 992332 reaction equation
[NH2:1][C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([C:12](Cl)=[O:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[NH2:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH2:17]1>>[F:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH2:21][N:18]2[CH2:19][CH2:20][CH:16]([NH:15][C:12]([C:4]34[CH2:10][CH:8]5[CH2:9][C:2]([NH2:1])([CH2:11][C@@H:6]([CH2:7]5)[CH2:5]3)[CH2:3]4)=[O:13])[CH2:17]2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 155038823-Aminotricyclo[3.3.1.13,7]decane-1-carbonyl chlorideHCID 59915932(S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine

Product 1

HCID 70176410HCID 70176410, compound

Procedure

1-Aza-5-methyladamantane-3-carbonyl chloride and (S)-3-amino-1-(2-(4-fluorophenyl)ethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-(4-fluorophenyl)ethyl)pyrrolidin-3-yl)-1-aza-5-methyladamantane-3-carboxamide.

Sources & evidence

ORD record
ord-1f80d3adcfb6480089418b2b6e343f95
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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