(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine → HCID 70176420, compound

HRID 992342Notes

Reaction equation

HRID 992342 reaction equation
[NH2:1][C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([C:12](Cl)=[O:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.[NH2:15][C@H:16]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:17]1>>[C:23]1([CH2:22][CH2:21][N:18]2[CH2:19][CH2:20][CH:16]([NH:15][C:12]([C:4]34[CH2:10][CH:8]5[CH2:9][C:2]([NH2:1])([CH2:11][C@@H:6]([CH2:7]5)[CH2:5]3)[CH2:3]4)=[O:13])[CH2:17]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamineHCID 155038823-Aminotricyclo[3.3.1.13,7]decane-1-carbonyl chloride

Product 1

HCID 70176420HCID 70176420, compound

Procedure

1-Aza-5-methyladamantane-3-carbonyl chloride and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-aza-5-methyladamantane-3-carboxamide.

Sources & evidence

ORD record
ord-b9dfce7ca99c46598d52da40ddf4d7dc
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Reaction notes

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