4-(4-Phenoxyphenyl)piperidine → 4-(4-Phenoxyphenyl)-1-[3-(2,3,4-trimethoxyphenyl)-2-propenyl]piperidine

HRID 992369Notes

Reaction equation

HRID 992369 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[C:31]([O:32][CH3:33])=[C:30]([O:34][CH3:35])[CH:29]=[CH:28][C:23]=1[CH:24]=[CH:25][CH2:26]Br>>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH2:26][CH:25]=[CH:24][C:23]3[CH:28]=[CH:29][C:30]([O:34][CH3:35])=[C:31]([O:32][CH3:33])[C:22]=3[O:21][CH3:20])[CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 110759844-(4-Phenoxyphenyl)piperidineHCID 54290809(2,3,4-Trimethoxy)cinnamyl bromide

Product 1

HCID 544367994-(4-Phenoxyphenyl)-1-[3-(2,3,4-trimethoxyphenyl)-2-propenyl]piperidine

Procedure

The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and (2,3,4-trimethoxy)cinnamyl bromide to produce the above.

Workup

  1. customto produce the above

Sources & evidence

ORD record
ord-4e594444d554428d9cb595675c1305b9
Source dataset
uspto-grants-2002_10
Patent number
US06469010B1

Reaction notes

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