4-(4-Phenoxyphenyl)piperidine → (E)-1-[3-(4-fluorophenyl)-2-propenyl]-4-(4-phenoxyphenyl)piperidine
Reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:20][C:21]1[CH:30]=[CH:29][C:24]([CH:25]=[CH:26][CH2:27]Br)=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:30]=[CH:29][C:24](/[CH:25]=[CH:26]/[CH2:27][N:17]2[CH2:18][CH2:19][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([O:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:9][CH:10]=3)[CH2:15][CH2:16]2)=[CH:23][CH:22]=1Participants
3
Procedure
The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and 4-fluorocinnamyl bromide to produce the above.
Workup
- customto produce the above
Sources & evidence
- ORD record
- ord-69c27dfe3bd541358c7594f1795c2626
- Source dataset
- uspto-grants-2002_10
- Patent number
- US06469010B1
Reaction notes
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