HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 992469Generated: November 1, 2026
3,5-Dimethyl-1H-pyrrole-2-carbaldehyde → 3-[(2,3-Dimethylpyrrol-5-yl)methylene]-2-indolinone
https://huagongshe.com/reaction/992469
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,5-Dimethyl-1H-pyrrole-2-carbaldehyde | HCID 270465 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(2,3-Dimethylpyrrol-5-yl)methylene]-2-indolinone | HCID 5250044 | 57% |
Reaction Steps
A reaction mixture of 134.0 mg of oxindole, 147.8 mg of the 3,5-dimethylpyrrole-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 136.7 mg (57%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06469032B2 |
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| Source dataset | uspto-grants-2002_10 |
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| ORD ID | ord-8abc047c059547c4a7c9f6a93d74c55f |
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| Source note | uspto-grants-2002_10 |
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