反应详情

3.65 g (12.5 mMol) of 1-methyl-2-[(4-cyanophenyl)-oxymethyl]-5-hydroxymethyl-imidazo[4,5-b]pyridine were dissolved in 500 ml dichloromethane and mixed with 15.0 g of manganese dioxide. After 96 hours at room temperature the mixture was filtered through kieselgur and the solvent was distilled off. The filtrate obtained was evaporated down, the crystalline precipitate was triturated with ether, suction filtered and dried.

1. filtrationAfter 96 hours at room temperature the mixture was filtered through kieselgur
2. distillationthe solvent was distilled off
3. customThe filtrate obtained
4. customwas evaporated down
5. customthe crystalline precipitate was triturated with ether, suction
6. filtrationfiltered
7. customdried