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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 992614Generated: October 26, 2026

Sodium Hydroxide → Dabigatran

https://huagongshe.com/reaction/992614

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantEthyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochlorideHCID 18412337—
ProductDabigatranHCID 216210—

Reaction Steps

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide-hydrochloride and sodium hydroxide solution.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06469039B1
Source datasetuspto-grants-2002_10
ORD IDord-b8275a755a8945db876b4c3733e98f8a
Source noteuspto-grants-2002_10