反应详情

A solution of 0.75 g (4.02 mMol) of methyl 5-amino-6-chloro-nicotinate and 0.43 g=0.35 ml (4.5 mMol) of methoxyacetylchloride in 20 ml of chlorobenzene was stirred for one hour at 110° C. After the solvent had been removed in vacuo the crude product obtained was purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1), evaporated down again in vacuo and then digested with petroleum ether.

1. customAfter the solvent had been removed in vacuo the crude product
2. customobtained
3. customwas purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1)
4. customevaporated down again in vacuo