Methoxyacetyl chloride → Methyl 6-chloro-5-methoxyacetamidonicotinate

HRID 992639노트

반응식

HRID 992639 반응식
[NH2:1][C:2]1[C:3]([Cl:12])=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[CH3:13][O:14][CH2:15][C:16](Cl)=[O:17]>ClC1C=CC=CC=1>[Cl:12][C:3]1[C:2]([NH:1][C:16](=[O:17])[CH2:15][O:14][CH3:13])=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:4]=1

참가 물질

4

반응물 2

HCID 96623Methoxyacetyl chlorideHCID 18412438Methyl 5-amino-6-chloropyridine-3-carboxylate

생성물 1

HCID 18412377Methyl 6-chloro-5-methoxyacetamidonicotinate

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

A solution of 0.75 g (4.02 mMol) of methyl 5-amino-6-chloro-nicotinate and 0.43 g=0.35 ml (4.5 mMol) of methoxyacetylchloride in 20 ml of chlorobenzene was stirred for one hour at 110° C. After the solvent had been removed in vacuo the crude product obtained was purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1), evaporated down again in vacuo and then digested with petroleum ether.

후처리

  1. customAfter the solvent had been removed in vacuo the crude product
  2. customobtained
  3. customwas purified by flash chromatography (silica gel; methylene chloride/ethanol=100:1)
  4. customevaporated down again in vacuo

출처 및 근거

ORD 기록
ord-e501b31b1e9b414b94e89ab59e3c17be
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06469039B1

반응 노트

불러오는 중…