Trichloroacetyl chloride → 2-(Trichloroacetyl)pyrrole

Participants

Reaction Steps

2-(Trichloroacetyl)pyrrole was prepared from pyrrole (12.5 g, 186 mmol) and trichloroacetyl chloride (36.5 g, 200 mmol) according to the method of Bailey et al, Org. Synth., 1971, 100. In this manner the title compound (31.3 g, 80%) was obtained as a cream solid, m.p. 73-74° C. (lit. m.p. 73-75° C.). 1H n.m.r. d 9.30, broad s, 1H; 7.39, m, 1H; 7.17, m, 1H; 6.40, dt, J 3.9 and 2.4 Hz, 1H. (see also J. Org. Chem., 1972, 37, 3618; 1993, 58, 7245).

Provenance & Evidence