Water → HCID 18411652, compound

HRID 992693Notes

Reaction equation

HRID 992693 reaction equation
[C-:1]#[N:2].[Na+].Cl[CH2:5][C:6]1[CH:7]=[N:8][N:9]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1.O>CS(C)=O>[C:1]([CH2:5][C:6]1[CH:7]=[N:8][N:9]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1)#[N:2]

Participants

5

Reactant 3

HCID 962WaterHCID 8929Sodium CyanideHCID 18411579HCID 18411579, compound

Product 1

HCID 18411652HCID 18411652, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Under nitrogen atmosphere, sodium cyanide (540 mg) was added to a solution of 4-chloromethyl-1-tritylpyrazole (3.58 g) in dimethylsulfoxide (30 ml) at 50° C. After stirring for 1 hour, the mixture was poured into water. The organic layer was separated, washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated, to afford 4-cyanomethyl-1-tritylpyrazole (3.41 g).

Workup

  1. customThe organic layer was separated
  2. washwashed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-21a2139513e14216ba9d55b5e93895eb
Source dataset
uspto-grants-2002_10
Patent number
US06468995B1

Reaction notes

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