Isopropanol → HCID 88179714, compound

Participants

Reaction Steps

Under nitrogen atmosphere, trifluoroacetic acid (2.0 ml) was added dropwise to a solution of diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-[(1,2,3-thiadiazol-5-yl)methylthio]-3-cephem-4-carboxylate (1.02 g) in anisole (1.0 ml) and dichloromethane (3.0 ml) under ice cooling. The mixture was stirred for 1 hour at room temperature, and then poured into 150 ml of isopropanol. The resulting precipitate was collected by filtration and treated on HP-20 (eluent: water-methanol) to afford 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-[(1,2,3-thiadiazol-5-yl)methylthio]-3-cephem-4-carboxylic acid (193.3 mg).

Provenance & Evidence