Hydrochloric Acid → HCID 88157657, compound

Participants

Reaction Steps

To a solution of 1-(cyclohexyloxycarbonyloxy)ethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylate (166 mg) in a mixture of ethyl acetate (5 ml) and THF (5 ml) was added 4N hydrogen chloride in ethyl acetate (0.127 ml) under ice-cooling. The mixture was stirred at the same temperature for 10 minutes, and then the resulting precipitates was collected by filtration to give 1-(cyclohexyloxy-carbonyloxy)ethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylate dihydrochloride (164 mg).

Provenance & Evidence