Benzene, 1-iodo-4-(trifluoromethyl)- → 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one

Participants

Role	Name	HCID	Charge
Reactant	Benzene, 1-iodo-4-(trifluoromethyl)-	HCID 67993	—
Reactant	1,4-Tetrahydrothiazine-3-one	HCID 88402	—
Catalyst	Copper	HCID 23978	—
Product	4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one	HCID 12083010	23.3%

Reaction Conditions

Temperature	192.5 °C

Reaction Steps

A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06472388B2
Source dataset	uspto-grants-2002_10
ORD ID	ord-3035de4943de42e2821f5d8cbb4876e6
Source note	uspto-grants-2002_10