3-Chloro-1-propanol → HCID 18408622, compound

Participants

Reaction Steps

855 mg (3mmol) of 3-iodo-4-methyl-5-phenyl-1,2,4-(4H)-triazole (prepared by iodinating 4-methyl-5-phenyl-1,2,4-(4H)-triazole by a method similar to Izv. Akad. Nauk SSSR, Ser. Khim (1975), 616-619), were stirred, at 60° C. for 6 h, with 1.04 g (3 mmol) of 2-t-butyl-4-[4-(3-hydroxypropyl)piperazin-1-yl]-6-trifluoromethyl pyrimidine (prepared, by a method similar to Example 1, A.3, by reacting the product obtained as described in Example 1, A.2 with 3-chloropropanol) and sodium hydride in DMF. For the working-up, ice water was added to the mixture and the whole was extracted several times with methyl t-butyl ether. The residue which was obtained after drying with sodium sulfate and removing the solvent was purified by column chromatography (silica gel, methylene chloride/methanol). Yield, 140 mg (9% of theory) of oil.

Provenance & Evidence