Hexahydro-1,4-diazepine → HCID 10283326, compound

HRID 993002Notes

Reaction equation

HRID 993002 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:8]#[C:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)[S:6][CH:7]=1.[NH:22]1[CH2:28][CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH3:21][O:20][C:12]1[CH:11]=[C:10]([C:9]#[C:8][C:5]2[S:6][CH:7]=[C:3]([CH2:2][N:22]3[CH2:28][CH2:27][CH2:26][N:25]([CH2:2][C:3]4[N:4]=[C:5]([C:8]#[C:9][C:10]5[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=5)[S:6][CH:7]=4)[CH2:24][CH2:23]3)[N:4]=2)[CH:15]=[C:14]([O:16][CH3:17])[C:13]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 18408506HCID 18408506, compound

Product 1

HCID 10283326HCID 10283326, compound

Procedure

4-Chloromethyl-2-(3,4,5-trimethoxyphenylethynyl)-thiazole (126 mg) and homopiperazine (19 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-6e0cb68cb04246e9a1f49437d32aee77
Source dataset
uspto-grants-2002_10
Patent number
US06472386B1

Reaction notes

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